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L’utilité de ce genre d’institutions est incontestable. Car le monde moderne est sans cesse confronté à des innovations, médicales ou autres, qui s’appliquent à l’homme ou à son environnement proche. Ce lieu est donc nécessaire pour préparer la matière intellectuelle qui sera ensuite transférée aux citoyens afin que ceux- ci puissent se prononcer quant à la légitimité de ces innovations.

 

Professeur Axel Kahn, le célèbre généticien français, lors de l’inauguration de la Fondation Brocher

 

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Le Cycle Brocher organise de nombreuses conférences au cours de l'année. La plupart des conférences sont disponibles en podcast

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13 - 15 mai 2025

Exploring the applicability of the '14-day rule' in human stem-cell-based embryo models: defining ethical boundaries.

Organisateurs:

Introduction:

Exploring the applicability of the '14-day rule' in human stem-cell-based embryo models: defining ethical boundaries.

For over four decades, the use of human embryos in scientific research has ignited impassioned debates around ethics and governance. As we stand on the precipice of technological advancements that allow us to create increasingly realistic models of human embryos, the time is ripe to discuss the familiar and novel ethical dilemmas raised by these recent scientific developments. These models are developed from stem cell lines to recapitulate the early embryo at various stages and levels of fidelity to the embryo. Specifically, advancements in this field add to the increasing debate regarding the unsuitability of the currently widely adopted ’14-day rule’ which posits that embryo culture should be limited to 14 days or the emergence of the primitive streak (PS). Can this rule be upheld in the context of embryo models? If not, should alternative ethical boundaries be imposed on human embryo model culture, and if so, which ones? How should we respond to ethical issues raised by embryo models as  technology advances?

In this workshop, we will bring together a select group of experts from Europe and beyond who are at the forefront of the bioethical, regulatory, and scientific discussions on embryo model research. Together, we aim to co-design a new, theoretically robust, and practically concrete framework for research with different embryo models. Moreover, this workshop aims to facilitate the creation of an international, interdisciplinary network of embryo model experts in the fields of bioethics, law, biomedical science, and policymaking who can both exchange perspectives, set research agendas, and impact contemporary policymaking, and facilitate future responsiveness to developments in the field. Project outcomes will include a book, a scientific article and a lay resource, with editors at respectively Springer, Nature Methods and EuroGCT already on board. All in all, we expect the workshop to make a significant contribution to this timely discussion and seed future collaborative responses.